Core Nutritionals Daily Health Pack
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We understand that being consistent with taking all your supplements can be tough, especially when your lifestyle is busy and schedule is full. At Core Nutritional’s®, we recognize this and put together a convenient daily packet that has everything you need to support your Crush It® lifestyle inside and outside of the gym. We’ve packed a combination of micronutrients, omega-3, probiotics, greens and reds, and products to support vital joints and organs, that can be highly beneficial to their overall function. Overall, a convenient daily pack of these supplements can help individuals maintain their health, support key body functions, and optimize well-being, even during a hectic and unpredictable lifestyle.
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B Vitamins (Thiamine, Riboflavin, Niacin, B6 [Pyridoxine], Folic Acid, B12, Biotin, and Pantothenic acid)
B vitamins are a group of eight essential vitamins with several critical functions in the body. Though both molecularly and physiologically distinct, they are also deeply interrelated in their effects, synthesis, and metabolism. Among the B-complex’s many critical roles are energy (protein, carbohydrates, and fat) metabolism, supporting and maintaining the healthy function of the adrenal glands, skeletal muscle function, and digestion.
While rates of metabolism and clearance differ between each B vitamin, all B vitamins are water-soluble and are thus not stored in fat. As a result, the body simply excretes excess B vitamins in the urine and requires replenishment (from food or supplements) to maintain the cell functions to which B vitamins contribute.
Vitamin A (as retinyl palmitate)
Beta carotene is itself not an essential vitamin but is rather the precursor to the fat-soluble and essential vitamin, vitamin A (Retinol). Like B vitamins, the term vitamin A refers to the compound class retinoids, comprised of retinol, retinal (also called retinaldehyde), retinoic acid, and provitamin A compounds such as beta carotene.
As their names suggest, retinoids are critical to the function of human eyes and therefore to the maintenance of circadian rhythms (our “biological clock”). Vitamin A combines with proteins in the eye to form light-sensing cells that both facilitate vision and regulate our sleep-wake cycles.
Beyond its role in sight, vitamin A is also essential for cellular growth and differentiation and the immune system.
Vitamin C (as Ascorbic Acid)
Vitamin C is perhaps historically best-known for the treatment and prevention of scurvy, though it has many other roles in the body. For example, vitamin C catalyzes or is a cofactor in eight enzymatic reactions involved in the synthesis of collagen, the nutrient carnitine, and several neurotransmitters necessary for the proper function of the brain.
In the contemporary context, vitamin C is best known as a potent antioxidant. In addition to its intrinsic activity as an antioxidant, vitamin C has been shown in in vitro trials to regenerate alpha-tocopherol (vitamin E). As an antioxidant, vitamin C combats the detrimental effects of a group of compounds called radical oxygen species that, when produced, degrade the lipid membrane of the cell, and may cause internal damage. By “scavenging” these free radicals, vitamin C and other antioxidants form a defense against excess cellular damage.
Vitamin D3 (as Cholecalciferol)
Vitamin D, in its various forms, is not an essential nutrient – as it is produced endogenously within the body, as a reaction to the skin’s exposure to the sun – and thus not commonly considered a vitamin. Despite its technical classification, vitamin D (a hormone), is nevertheless an import and biologically-active compound, necessary for the calcium homeostasis and metabolism, along with increasing the absorption of magnesium and phosphate.
Vitamin E (as dl-alpha tocopherol acetate)
Vitamin E is another technical misnomer, as the term refers to a group of compounds known as tocopherols with eight biologically-active constituents: alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol. Alpha-tocopherol is the principal bioactive in humans, though the presence of other tocopherols has been linked to beneficial effects.
As a result of its robust antioxidant activity, vitamin E assists in the maintenance and support of several physiological processes, though most notably sight and the immune system. Emerging research also suggests that the alpha-tocopherol form of vitamin E inhibits an enzyme known as protein kinase C, and therefore contributes to the healthy regulation of smooth muscle cell growth and differentiation.
Calcium (as dicalcium malate (DimaCal®)
While best-known as the main bioactive in milk, and a compound that contributes to strong bones, calcium has numerous physiological effects in the body – including mediating vascular contraction and vasodilatation, muscle function, nerve transmission, intracellular signaling, and hormonal secretion. Homeostatic regulation of calcium, which the body cannot produce, requires sufficient levels of vitamin D.
When present in sufficient amounts, calcium is necessary for the adequate formation, function, and remodeling of both bone and teeth. Insufficient levels of calcium are associated with degenerative bone and joint disorders such as osteoporosis, wherein bone accretion slows or stops; thereby reducing bone mass and density and decreasing bone strength.
Iodine (as potassium iodide)
Iodine is a trace element naturally present in certain foods, including kelp. Iodine is a critical component for fetal development, especially during early pregnancy, as maternal T4 (thyroxine) is the sole source of fetal thyroid hormone. After birth, especially if breast-feeding, iodine remains an important constituent of a balanced-diet to maintain adequate T3 (triiodothyronine) and T4 (thyroxine) levels in the mother and for the proper cognitive development in the child.
As implied, however, the most important of iodine’s functions is assisting the body to produce and maintain healthy levels of both thyroid hormones and TSH (thyroid stimulating hormone, released by the pituitary). The thyroid hormones, in turn, regulate several critical biochemical reactions, including protein synthesis, and, along with norepinephrine/epinephrine, largely determine the body’s metabolic rate.
Magnesium (as Di-Magnesium Malate)
It is difficult to overstate the biological necessity of magnesium. Magnesium is a co-factor in over 300 enzymatic reactions that regulate essential physiological functions such as protein synthesis, glucose homeostasis, muscle and nerve function, and the maintenance and support of healthy blood pressure levels.
Magnesium is also required for the use of the body’s energy currency, ATP. To become biologically active, ATP must be bound to magnesium to form Mg-ATP. In addition, magnesium is necessary for the proper function of cells with calcium and potassium gated ion channels such as heart and muscle cells.
In men, magnesium (along with zinc) is necessary for the maintenance of healthy levels of testosterone.
Zinc (as Zinc Aspartate)
As an essential mineral, like magnesium, zinc is also involved in a wide-range of essential biological functions in the human body – and a requirement in the catalytic activity of over 100 enzymes.
Most notably, zinc is vital for immune function, protein synthesis, cellular division, and DNA synthesis. For immune function, zinc is required for the function of a group of immune cells known as neutrophils and macrophages, which eliminate pathological cells and their products from the body.
With magnesium, sufficient levels of zinc are also necessary for the production and maintenance of healthy levels of testosterone.
Copper (as Copper Bisglycinate Chelate)
Copper is a trace element necessary for the production, function, and maintenance of a diverse range of compounds involved in physiological function.
The brain, the heart, bone, and connective tissue specifically require copper or the enzymes it catalyzes to properly grow and differentiate their various cell types. Like many of the ingredients in Core MULTI, copper is also required for the homeostasis of other minerals, specifically zinc.
Manganese (as Manganese Citrate)
Manganese is a required element for not only humans, but all living organisms. Manganese primarily acts as an antioxidant, specifically scavenging a radical oxygen species known as superoxide.
Chromium (as Chromium Picolinate)
Chromium is an essential, though little understood, trace element found in certain foods and industrial compounds. Only one of chromium’s two forms, the form used in Core MULTI, chromium 3+, is biologically active.
While not as well-defined as other trace elements, chromium’s physiological actions nevertheless seem pivotal to the production and transmission of healthy levels of insulin. Emerging research also seems to suggest that chromium is directly involved in the metabolism of carbohydrates.
Molybdenum (as Molybdenum Glycinate Chelate)
Molybdenum is an essential trace element, involved in at least four enzymatic reactions necessary for urea excretion and several other physiological functions.
Chlorella and Spirulina Powder:
Chlorella and spirulina are the organisms behind the most common forms of green and blue/green algae, respectively. Chlorella has been variously classified as either a plant or a protist, while spirulina is a kind of cyanobacteria and thus classified as a bacterium. Regardless of the taxonomical differences between chlorella and spirulina, emerging evidence suggests that both have a range of benefits for human health.
The first benefit is that the macronutrient constituents in the plants themselves are favorable. Spirulina is a source of high-quality protein, γ-linolenic acid, and phycocyanin content. Chlorella, in turn, contains a variety of bioactives, including nucleic acids, amino acids, vitamins, minerals, polysaccharides, glycoproteins, and β-glucans.
In addition to their macronutrient content, both chlorella and spirulina contain bioactive compounds that emerging evidence suggests have potential health effects. Polypeptide chains isolated from chlorella, for example, were shown in in vitro and animal models to be potent ACE inhibitors. ACE (angiotensin converting enzyme) is an enzyme that catalyzes the conversion of inactive Angiotensin I (AG-I) to the active Angiotensin II (AG-II). In turn, AG-II binds to the Angiotensin II receptor in smooth muscle and elicits the production of aldosterone – creating a hypertensive effect through direct and indirect means. While still preliminary, evidence suggests that the isolated polypeptides in chlorella may be ACE inhibitors.
Similar trials on the reduction of HbA1C, for example, demonstrate that these microalgae and their constituent parts may indeed be superfoods.
PhytoServ® Fruit Blend and Veggie Blend
PhytoServ® is a proprietary blend of plant-based extracts that condenses voluminous micronutrient sources into easy to deliver clinical doses that provide powerful antioxidant containing phytonutrients that can protect the body’s immune system from the harmful effects of oxidative stress. In the Fruit Blend you will receive a combination of:
- Grape Seed Extract
- Wild Blueberry Extract
- Raspberry Extract
- Tart Cherry
- Wild Bilberry Extract
In the Veggie Blend you will receive:
- Broccoli Sprout
- Onion Extract
- Brussels Sprout
In the Core DAILY HEALTH PACK, we have included both the Fruit Blend and Veggie Blend so there are no gaps to your micronutrient protection.
Of the known choline pro-drugs or precursors, Alpha GPC appears to have exert the greatest influence on circulating choline levels. Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for several functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk/reward, arousal, and enhancing memory.
Choline’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.
Whether through these, or other independent mechanisms, a recent trial using Alpha GPC demonstrated a statistically significant increase to power output. In a placebo-controlled, double-blind, randomized trial, 14 healthy volunteers, split into an Alpha GPC or placebo group, were tested on various exercises. In comparison to the placebo group, the Alpha GPC group experienced a 14% increase to bench press. The researchers hypothesize that the peak power increase was the result of a substantial acute increase to growth hormone, one of the observed effects of Alpha GPC supplementation.
Bacopa Extract (50% Bacopasides) (Bacopa monnieri L.) (Leaf)
Bacopa monnieri, also known as the water hyssop commonly, or as Brahmi in Ayurvedic texts, is a small creeping herb endemic to sub-tropical India. The herb has been used in traditional Indian medicine for well over one thousand years, with its first recorded usage coming in the 6th century A.D. In this traditional context, BM has been used for a wide-range of purposes, including as a treatment of asthma and epilepsy.
More recently, BM has been the subject of numerous cognition and memory trials, as the plant has a well-established nootropic effect. Likely through modulation of the serotonin reuptake system, clinical trials in healthy humans have demonstrated that BM possesses a significant effect on the retention of newly-learned information. In several trials utilizing a 300mg daily serving, BM was also shown to decrease the recall delay of newly learned information and reduce short term forgetfulness – suggesting that the herb’s effect on the serotonic and cholinergic systems are increasing the encoding (the literal storing) of memory information.
Beyond cognition and memory encoding, BM has also been demonstrated to function as a potent adaptogen and relaxant – which in the Core DAILY HEALTH PACK brain formula may help to smooth the effect curve of the product’s stimulants, reducing jitteriness or, “crash.”
Coffee Fruit Extract (Coffea arabica) (Fruit) (CognatiQ®)
CognatiQ®, an extract derived from the whole fruit Coffea arabica plant, is a clinically proven ingredient shown to stimulate the production of the neuroprotein, Brain-Derived Neurotrophic Factor (BDNF). BDNF has been shown to be crucial in the development, maintenance and repair of neurons and also protect against neuro-degeneration. One study comparing other coffee, caffeine, and polyphenol compounds, showed that they were not statistically significant in increasing BDNF % compared to CognatiQ®. The unique polyphenol profile found in CognatiQ® showed to be superior in increasing BDNF concentration.
Huperzia serrata Extract (std. 1% Huperzine A)
Huperzia serrata is a compound found in the plant families of Huperziaceae, Lycopodiaceae, and Selaginella and is endemic to China. The Lycopodium alkaloid Huperzine-A, found in Core ZONE, was first isolated from a folk medicinal preparation in 1984.
This potent compound has been evaluated in numerous in vitro, in vivo, and human trials. These data suggest that Huperzine A’s mechanisms of action are most potent in the cortex, hippocampus, and striatum (at least in rats) – key regions in the brain responsible for forming, coordinating, and recalling memory. These effects are assisted by Huperzine A’s high oral bioavailability. Studies using microdialysis technique in rats, for example, showed that the response to Huperzine A was dose-dependent and substantially lowered the level of ACh in cortex.
Huperzine A has also shown promise in humans. Referred to as an inhibitor of acetylcholinesterase, Huperzine A has shown positively impact cognition and memory. This is partly due to its inhibitory factors on acetylcholinesterase (an enzyme that breaks down acetylcholine), which results in an increase in acetylcholine. Acetylcholine is known as a learning neurotransmitter so increased levels can be beneficial towards memory, and other neural improvements. In another study on memory and learning performance, 34 pairs of middle school students complaining of memory inadequacy were given a small dose of Huperzine A. The students were then match paired along several vectors and provided tests on working memory. The results of this study exhibited that HupA markedly improved the memory function of adolescent students.